An Early Model of Bipolar Illness Postulated That a Single

Essay

An early model of bipolar illness postulated that a single gene was responsible for the phenotype. This led to the "discovery" of a locus on chromosome 11 thought to be the gene responsible for this behavioral abnormality. Further work caused the retraction of this discovery, but the issues raised in this case have not been fully resolved. What are the problems associated with a single gene model, and how do they affect the search for the gene?