LFA-1 Is an Integrin That Promotes T Cell Activation by Which

Multiple Choice

LFA-1 is an integrin that promotes T cell activation by which one of the following mechanisms?

A) Binds to the α3 domain of class I MHC molecules, mediating high avidity between T cells and antigen-presenting cells (APCs)
B) Binds to B7-1 or B7-2 on the surface of APCs, mediating "signal 2"
C) Binds to GlyCAM-1 on high endothelial venules of lymph nodes, mediating rolling of T cells on endothelium
D) Binds to ICAM-1 on the surface of a variety of cells, mediating firm adhesion between T cells and APCs or endothelial cells
E) Binds to VCAM-1 on the surface of cytokine-activated endothelial cells, mediating homing of T cells to peripheral sites of inflammation