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In the First Step of a Solid-Phase Peptide Synthesis, an Fmoc-Amino

Question 21

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In the first step of a solid-phase peptide synthesis, an Fmoc-amino acid reacts with a chloromethyl group on the resin. (a) Draw a curved-arrow mechanism and draw the amino acid linked to the resin. (b) explain why a Fmoc group is needed and how to remove it.
In the first step of a solid-phase peptide synthesis, an Fmoc-amino acid reacts with a chloromethyl group on the resin. (a) Draw a curved-arrow mechanism and draw the amino acid linked to the resin. (b) explain why a Fmoc group is needed and how to remove it.

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(a) The first step of the mechanism is d...

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