The X-Linked Variant of Charcot-Marie-Tooth Disease Is Likely Caused by Mutations

Essay

The X-linked variant of Charcot-Marie-Tooth disease is likely caused by mutations in a gene encoding a probable connexin 32. Suppose your laboratory is working with a human cell line called HeLa cells, which do not express connexins. Propose an experiment to demonstrate that the probable wild-type connexin 32 is actually a gap junction protein.