Essay
Suppose that a single protein is significantly overexpressed in one of two different cell lines. The proteins are identical, but Northern blot analysis indicates that the mRNA for the protein in the overexpressing cell line is about 200 base pairs shorter. Subsequent reverse transcriptase PCR has revealed that the truncation occurs in the 3ʹ untranslated region. How might this lead to overexpression of the protein?
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The 3ʹ UTR can serve several roles in re...View Answer
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