Estimates of Mutation Rates for a Variety of Genes Indicate

Multiple Choice

Estimates of mutation rates for a variety of genes indicate that the frequency of errors during replication is much lower than would be predicted on the basis of complementary base pairing. What accounts for the higher degree of fidelity?

A) Conformational changes in DNA polymerase
B) 3ʹ to 5ʹ exonuclease activity of DNA polymerase
C) Requirement of a primer for DNA synthesis by DNA polymerase
D) All of the above