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You Have a Cell Signaling Cascade in Which a Cell

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You have a cell signaling cascade in which a cell signal initially targets and activates protein 1 which in turn activates protein 2 which then activates protein 3 and finally activates protein 4. You are given a cell line that never expresses protein 2, yet in every experiment in which you give the initiating signal, you get activation of protein 4. How could you explain these results?

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Somehow, the signal is being appropriate...

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