Why Is It Difficult to Accurately Identify Transcription Factor Binding

Multiple Choice

Why is it difficult to accurately identify transcription factor binding sites by scanning the genome sequence? Please select all that apply.

A) Transcription factor binding sites are variable
B) Transcription factors bind to RNA, not DNA
C) The distance between the transcription start site and the transcription factor binding site is variable
D) Transcription factor binding sites are usually long