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In Vertebrate Nervous System Development, What System Is Responsible for Sharpening

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In vertebrate nervous system development, what system is responsible for sharpening the homeobox gene expression boundaries between rhombomeres? How does this system work with respect to what the key players are, where they are located, how they interact, and how they influence gene expression and rhombomere boundaries? What does this mean for the fate of the cells that make up each rhombomere?

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