When Discussing Ophthalmic Solutions, Which of the Following Is False

Multiple Choice

When discussing ophthalmic solutions, which of the following is false?
I. Ophthalmic solutions can be used with contact lenses in place.
II. Patients should pull out the lower eyelid to form a pocket to place ophthalmic drops.
III. Different ophthalmic preparations should be applied at least 10-20 minutes apart.
IV. Ophthalmic solutions have no systemic effects.

A) I only
B) III only
C) I, II, and III
D) I and IV only