A 43-Year-Old Man with Severe Acquired Aplastic Anemia Has Not

Multiple Choice

A 43-year-old man with severe acquired aplastic anemia has not responded to immunosuppressive agents. He remains neutropenic and transfusion-dependent for platelets and red cells. He has an HLA-identical brother who has been cleared as a donor for his planned allogeneic stem cell transplant.They are both cytomegalovirus-seronegative. Which of the following would be prevented by using irradiated cellular blood products for this patient?

A) Cytomegalovirus disease
B) Alloimmunization
C) Transfusion-related graft-versus-host disease
D) Febrile nonhemolytic transfusion reaction
E) Hemolytic transfusion reaction