Clarissa Had Used OxyContin for Years After a Back Injury

Multiple Choice

Clarissa had used OxyContin for years after a back injury. Her doctor became concerned after she did not come in for a required pill count and refused to refill her prescription. At first Clarissa needed the OxyContin, but by the third week without the drug, Clarissa's cravings were so intense that she switched to Opana, another opioid that she could buy on the street more easily. Which of the following is true of Clarissa?

A) She relapsed due to her lack of willpower.
B) She thought her drug cravings were becoming worse, but her brain was becoming less dependent on opioids.
C) Connections between her amygdala and prefrontal cortex became silent, which urged her to relapse.
D) Her cravings were getting worse as connections between her amygdala and nucleus accumbens became functional.