Which of the Following Order of Events Is Most Accurate

Multiple Choice

Which of the following order of events is most accurate for activation of G-protein coupled receptor (GPCR) signaling pathways?

A) Hormone binds GPCR, GPCR binds with G protein, G protein loses GDP and gains GTP, G-protein alpha subunit activates intracellular proteins.
B) Hormone binds GPCR, G protein loses GDP and gains GTP, GPCR binds with G protein, G-protein alpha subunit activates intracellular proteins.
C) Hormone binds GPCR, GPCR binds with G protein, G-protein alpha subunit activates intracellular proteins, G protein loses GDP and gains GTP.
D) Hormone binds GPCR, G protein loses GDP and gains GTP, G-protein alpha subunit activates intracellular proteins, GPCR binds with G protein.
E) GPCR binds with G protein, hormone binds GPCR, G protein loses GDP and gains GTP, G-protein alpha subunit activates intracellular proteins.