Clearance (CL) of a Drug Is Defined as Which of the Following

Multiple Choice

Clearance (CL) of a drug is defined as which of the following?

A) The rate of elimination by all routes normalized to the concentration of drug, in some biological fluids
B) A measure of the apparent space the body has available to contain the drug
C) The time required for an amount of drug in blood to decline to one-half its measured value
D) The fraction of drug dose reaching the systemic circulation following administration by any route