Which of the Following Is Considered a Significant Problem with Using

Multiple Choice

Which of the following is considered a significant problem with using biomarkers of bone turnover in the management of patients with osteoporosis in a clinical setting?

A) They can be repeated over short time intervals thus providing quick results.
B) They are noninvasive.
C) They require no special patient preparation.
D) The measurements are affected by several preanalytical variables both controllable and uncontrollable.