Multiple Choice
In the chymotrypsin mechanism, what is used to stabilize the negative charge on the carbonyl oxygen of the transition state?
A) hydrogen bonding between the enzyme and the anion from the carbonyl oxygen
B) electrostatic interaction of the positively charged His and carbonyl oxygen
C) electrostatic interaction of the negatively charged Asp and carbonyl oxygen
D) electrostatic interaction of the active site Zn2+ and carbonyl oxygen
E) all of the above
Correct Answer:
Verified
Correct Answer:
Verified
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