Which Best Describes the Logic Behind Shotgun Sequencing

Multiple Choice

Which best describes the logic behind shotgun sequencing?

A) Fragment the genome into short pieces. Sequence each piece. Use overlapping ends to assemble the pieces in the correct order.
B) Start with one end of each chromosome. Sequence straight through to the other end of the chromosome.
C) Use a variety of techniques to identify genes and open reading frames. Sequence these segments but not the noncoding and repeated sequences.
D) Fragment the genome into pieces. Map the location of each piece. Then sequence each piece.