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Pedigree Analysis Was Used to Determine Whether a Genetic Marker

Question 58

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Pedigree analysis was used to determine whether a genetic marker is inherited with a disease trait (black circle) . Results of Southern blot analysis of restriction endonuclease-digested DNA from members of the family are shown. What conclusions can be drawn from the data? Pedigree analysis was used to determine whether a genetic marker is inherited with a disease trait (black circle) . Results of Southern blot analysis of restriction endonuclease-digested DNA from members of the family are shown. What conclusions can be drawn from the data?   A)  A restriction fragment length polymorphism (RFLP)  is linked to this autosomal recessivetrait. B)  A restriction fragment length polymorphism (RFLP)  is linked to this autosomal dominanttrait. C)  The disease is caused by expansion of a trinucleotide repeat. D)  No information can be gained from this analysis because researchers should haveperformed a Northern blot, not a Southern blot.


A) A restriction fragment length polymorphism (RFLP) is linked to this autosomal recessivetrait.
B) A restriction fragment length polymorphism (RFLP) is linked to this autosomal dominanttrait.
C) The disease is caused by expansion of a trinucleotide repeat.
D) No information can be gained from this analysis because researchers should haveperformed a Northern blot, not a Southern blot.

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