Essay
Replacing an A with a T in a hemoglobin gene is associated with sickle-cell anemia in humans.
Normal: 5′-ATGGTGCACCTGACTCCTGAGGAGAAGTCT-3′
Sickle cell: 5′-ATGGTGCACCTGACTCCTGTGGAGAAGTCT-3′
(a) What is the nucleotide sequence of the normal and sickle-cell hemoglobin mRNA?
(b) What is the amino acid sequence in this part of the polypeptide chain, and what is the amino acid replacement that results in sickle-cell hemoglobin?
(c) Why might this amino acid substitution make a difference in protein structure?
Correct Answer:
Verified
(a) Normal: AUGGUGCACCUGACUCCUGAGGAGAAGU...View Answer
Unlock this answer now
Get Access to more Verified Answers free of charge
Correct Answer:
Verified
View Answer
Unlock this answer now
Get Access to more Verified Answers free of charge
Q10: You treat cells with an inhibitor of
Q11: Provide an explanation for why you should
Q12: You have determined the amino acid sequence
Q13: The "wobble hypothesis" states that<br>A) alternative (non-Watson-Crick)
Q14: Describe a specific example of control of
Q16: Which of the following illustrates quaternary protein
Q17: The frequencies with which different codons are
Q18: Short unstructured regions of a protein that
Q19: Use a rough diagram to compare the
Q20: An alpha helix is stabilized by<br>A) van