How Would a Hydrophilic Hormone NOT Regulate Target Gene Transcription

Multiple Choice

How would a hydrophilic hormone NOT regulate target gene transcription?

A) Via signal transduction
B) By binding to a specific hormone receptor on the plasma membrane
C) By initiating phosphorylation of target proteins inside the cell
D) By crossing the plasma membrane and binding to a hormone response element in the nucleus
E) By stimulating production of a secondary messenger such as cAMP