What Should Be Done Before Trying to Interpret Individual Regression

Multiple Choice

What should be done before trying to interpret individual regression coefficients?

A) See whether there is an overall statistically significant relationship between the set of predictors and the outcome variable.
B) Verify that the set of predictors can explain a meaningful portion of the variation in the outcome variable.
C) Calculate the coefficient of multiple determination,or coefficient of determination,whichever is appropriate.
D) All of these are correct.
E) None of these are correct.