Which of the Following Statements Regarding Enzymes and Transition States

Multiple Choice

Which of the following statements regarding enzymes and transition states is correct?

A) Stabilization of the transition state must be less than stabilization of ES for catalysis to occur.
B) Binding of substrate to an enzyme often causes strain,thus promoting transition-state formation.
C) The transition-state conformation of an enzyme-catalyzed reaction is identical to the conformation seen in the uncatalyzed transition state.
D) Formation of the transition state always assures that the reaction will proceed to product.