Hydrogen Is Often Abstracted from Substrates as H⁺; However,electronegative Fluorine

Multiple Choice

Hydrogen is often abstracted from substrates as H⁺; however,electronegative fluorine cannot be readily eliminated.Which of the following explains how enzyme inhibitors be fashioned to overcome this?

A) by replacing H with F-F at positions where catalysis involves H removal as H⁺
B) by replacing H with F- at positions where catalysis involves H removal as H⁺
C) by replacing H with F+ at positions where catalysis involves H removal as H⁺
D) by replacing H with F at positions where catalysis involves H removal as H⁺