Canine Phosphofructokinase (PFK)deficiency Afflicts Springer Spaniels,affecting an Estimated 10% of the Breed.PFK

Multiple Choice

Canine phosphofructokinase (PFK) deficiency afflicts springer spaniels,affecting an estimated 10% of the breed.PFK is the glycolytic enzyme that phosphorylates fructose-1-phosphate and catalyzes the committed step in glycolysis.Given its critical role in glycolysis,one implication of the genetic defect resulting in PFK deficiency in dogs is _____.

A) early embryonic mortality
B) elevated blood-glucose levels in the dog's blood
C) an intolerance for exercise
D) a reduced life span