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What Is the Best Explanation for a Person Whose Karyotype

Question 5

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What is the best explanation for a person whose karyotype from blood cells shows nearly all cells to have trisomy 21 to have 10 clinical manifestations of Downsyndromeand an above-average intelligence?


A) The trisomy was a result of nondisjunction of paternal gametes instead of maternal gametes.
B) The person has pseudo-Down syndrome, in which environmental conditions caused the person to have development that mimics only the physical manifestations.
C) The person has genomic imprinting, in which the paternal number 21 chromosome is not expressed, and both maternally derived number 21 chromosomes are expressed.
D) The person has mosaicism of trisomy 21, with blood cells having a high proportion and neurons having a low proportion of cells, with three number 21 chromosomes.

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