In a Lysosomal Storage Disease,the Hydrolases of Lysosomes Are Released

Multiple Choice

In a lysosomal storage disease,the hydrolases of lysosomes are released from the cells,rather than being isolated into vesicles.What is one possible mechanism for this result?

A) A proton gradient within vesicles was not generated.
B) The ER was unable to produce lysosomal vesicles.
C) Lysosomal enzymes were not phosphorylated in the rER.
D) There is a lack of mannose-6-phosphatase activity.
E) There is a mutation in all hydrolase genes that results in loss of the signal peptide.