Epidemiologists at the CDC in Atlanta,GA,have Called You in to Investigate

Essay

Epidemiologists at the CDC in Atlanta,GA,have called you in to investigate an increased incidence of leukemia in a remote region of Africa. Shortly after arriving,an RNA virus was isolated from patients and found to induce leukemia in mice. At this point you don't know the mechanism or viral gene product associated with the development of leukemia. One of your lab assistants has isolated a variant of the virus and reports that this variant is missing a portion (20%)of the genome of the original virus. Furthermore,this variant does not induce leukemia in mice.
a)How would you determine which portion of the genome is associated with the development of leukemia?
b)How would you determine the viral mechanism and product associated with the development of leukemia?