Which Statement Is True About Disulfide Bonds and Protein Folding

Multiple Choice

Which statement is true about disulfide bonds and protein folding?

A) Disulfide bonds have no influence on protein folding since they only form after the protein adopts its native conformation.
B) Proteins occasionally adopt nonnative conformations and form improper disulfide bonds that can be reversed by the enzyme protein disulfide isomerase.
C) The folding of the native conformation is influenced more strongly by the formation of disulfide bonds than by the primary structure of a protein.
D) If a protein forms an improper disulfide bond it is irreversibly inactivated and must be targeted by the cell for degradation.