Which of the Following Is a Description Consistent with Chronic

Multiple Choice

Which of the following is a description consistent with chronic myelogenous leukemia (CML) ?

A) There are defects in the ras oncogene, TP53 tumor-suppressor gene, and INK4A, the gene encoding a cell-cycle regulatory protein.
B) The bone marrow and peripheral blood are characterized by leukocytosis and a predominance of blast cells. As the immature blasts increase, they replace normal myelocytic cells, megakaryocytes, and erythrocytes.
C) There is failure of B cells to mature into plasma cells that synthesize immunoglobulins.
D) The translocation of genetic material from genes 9 and 22 creates an abnormal, fused protein identified as BCR-ABL.