In Which Way Is the Transition State of an Enzyme-Catalyzed

Multiple Choice

In which way is the transition state of an enzyme-catalyzed reaction different from the transition state of the corresponding uncatalyzed reaction?

A) It has a higher free energy content.
B) It has less chemical stability and is therefore more reactive.
C) It is more similar to the conformation of the substrate, as a result of induced fit.
D) It is energetically more stable, because it makes favorable interactions with the enzyme.
E) It participates in the reaction by exchanging a proton with the substrate, in a process that is known as general acid-base catalysis.