How Do Large Polar Molecules,such as the Protein Hormones Secreted

Multiple Choice

How do large polar molecules,such as the protein hormones secreted by endocrine cells or bacteria ingested by white blood cells,leave or enter the cell?

A) ​by the process known as vesicular transport
B) by the process of osmosis
C) by selective passive transport 
D) by the help of large lipid carriers 
E) ​by the help of large protein carriers