DNA Helicase Inhibitors Are Well Studied as Potential Drug Targets

Multiple Choice

DNA helicase inhibitors are well studied as potential drug targets. What would you expect to see if DNA helicase activity is inhibited?

A) The replisome complex would not assemble on the oriC region.
B) The DNA cannot bend, so hydrogen bonds in the 13-mer region of oriC remain intact.
C) Helicase catalyzes ATP hydrolysis and DNA strands separation, so the helix cannot be unwound and strands will not separate.
D) Helicase carries the SSB protein to the open region of DNA, so hydrolysis and strand separation will not occur.
E) Helicase prevents reannealing of the separated strands, so strands would quickly reanneal and DNA replication cannot proceed.