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Use of Double Mutants Has Been Invaluable in Studying Developmental

Question 16

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Use of double mutants has been invaluable in studying developmental pathways. In C. elegans, sex is determined by the ratio of sets of autosomes to X chromosomes. A diploid male has one X, and diploid hermaphrodites have two X's. The loss-of-function gene her-1 produces XO worms that are hermaphrodites, but XX worms are unaffected. Mutation of a second gene, tra, causes the XX to develop as male. Given this information, what would be the phenotype of a tra, her-1 double mutant?


A) a male nematode
B) a female nematode
C) a hermaphrodite
D) an intersex variant
E) lethality

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