Once a Chromosomal Position for a Putative Gene Associated with Parkinson

Multiple Choice

Once a chromosomal position for a putative gene associated with Parkinson disease is verified, which of the following is a next step?

A) developing a FISH screening test to identify pre-Parkinson patients
B) determining whether this locus is mutated in all Parkinson patients
C) using a genome-wide linkage SNP panel to identify more minor genes
D) ascertaining all living and at-risk individuals who are family members of the affected test subjects
E) fine mapping of the linkage region to identify particular variants for influencing risk