50% Inhibition of RNA Pol II Occurs in Humans Exposed

Multiple Choice

50% inhibition of RNA pol II occurs in humans exposed to 10-25 ng/ml of α-amanitin but it takes only 7 ng/ml of α-amanitin to achieve the same result in nematodes.Can you suggest a possible explanation for this observation?

A) Worms are more closely related to the fungus that humans are
B) Humans are more closely related to the fungus that worms are
C) Fungal hyphae and nematodes may naturally compete for soil nutrients
D) Humans have evolved resistance to the toxin
E) Worms have evolved resistance to the toxin