How Does Pharmacodynamic Tolerance Develop

Multiple Choice

How does pharmacodynamic tolerance develop?

A) The most acute effect of alcohol occurs after the first few drinks in a day; because the liver can only process so much alcohol, these effects become less pronounced as more drinks are consumed.
B) Over sustained periods of using alcohol, the number or sensitivity of the neuroreceptors that respond to alcohol gradually decreases.
C) Sustained use of alcohol over months or years increases the sensitivity of GABA and dopamine receptors.
D) The amount of substance that can be used in a given period of time fluctuates based on circadian cycles and, in women, menstrual cycles.