All of the Following Can Describe Why ED₅₀ and TD₅₀

Multiple Choice

All of the following can describe why ED₅₀ and TD₅₀ values are not ideal for calculating a therapeutic index except:

A) the index uses a value based on 50% of subjects experiencing severe adverse effects.
B) the index uses a value based on only 50% of subjects experiencing therapeutic drug effects.
C) the index uses the ED₅₀ value, which is most common for reporting dose-effect curves.
D) no matter the size of the index, using 50% values suggests that an unacceptable number of patients will likely experience adverse effects.