Efflux Pumps Send Antibiotics Such as Tetracycline, Which Binds to the 30S

Multiple Choice

Efflux pumps send antibiotics such as tetracycline, which binds to the 30S subunit of bacterial ribosomes, out of the bacterial cells, enabling them to grow in the presence of antibiotics. Which of the following therapeutic approaches will be least effective?

A) Switch to an antibiotic that is not a substrate of the efflux pump.
B) Augment the treatment with an efflux inhibitor.
C) Increase the concentration of tetracycline.
D) Augment the treatment with an ATP synthase inhibitor.
E) None of the above approaches will be effective.