An SH2-Containing Protein Contains a Mutation That Changes Its Binding

Multiple Choice

An SH2-containing protein contains a mutation that changes its binding pocket such that tyrosine and phosphotyrosine bind with equal affinity.As a result,MEK activity:

A) decreases due to changes in Raf activation.
B) decreases due to allosteric inhibition of SH2-domain binding.
C) increases with ligand binding-induced dimerization.
D) does not change with receptor dimerization and transautophosphorylation.