In Disseminated Intravascular Coagulation (DIC),what Activates the Coagulation Cascade

Multiple Choice

In disseminated intravascular coagulation (DIC) ,what activates the coagulation cascade?

A) Cytokines,such as platelet-activating factor (PAF) ,and tumor necrosis factor alpha (TNF-a)
B) Thromboxane A causing platelets to aggregate and consume clotting factors
C) Tissue factor (TF) located in the endothelial layer of blood vessels and subcutaneous tissue
D) Endotoxins from gram-negative and gram-positive bacteria circulating within the bloodstream