Match the Types of Cryoglobulin with the Correct Description

Multiple Choice

Match the types of cryoglobulin with the correct description.

-Type I

A) Mixed cryoglobulins in which both constituent immunoglobulins are polyclonal.More than 90% contain IgM rheumatoid factor and IgG.These cryoglobulins are seen in a variety of autoimmune,systemic rheumatic diseases and persistent infections with immune complexes (e.g. ,bacterial endocarditis) .
B) Cryoglobulins composed of a single class;IgM and IgG classes most common;IgA or light-chain,single cryoglobulins seen less frequently.This type constitutes about 25% of cryoglobulins and is generally associated with multiple myeloma,macroglobulinemia,and other,rarer neoplastic proliferations of plasma cells and lymphocytes.
C) Cryoglobulins consist of two forms.The monoclonal form always has rheumatoid factor activity and usually is an IgM with k light chains.The second form is polyclonal IgG,which reacts with the monoclonal IgM rheumatoid factor.