A Strain of N

Multiple Choice

A strain of N.gonorrhoeae is isolated that does not have a plasmid.If a lysate is made from the bacterium it cannot degrade penecillin in an in vitro assay.When a cuture of this strain is grown in a solution that contains radioactive penicillin the amount of penecilllin found within cells is less than the amount found in a non-resistant strain.Sequence of the porin gene from the resitant strain does not have any mutations.What is the most likely mechanism of resistnace in this strain?

A) MtR mutation that results in inactivation or inhiition of MtR activity.
B) penA nonsense mutation.
C) penA missense mutation.
D) Genome carries pen^r gene.