To Create a Mouse Model of the Human Disease Hemophilia

Multiple Choice

To create a mouse model of the human disease Hemophilia A,in which a nonfunctional factor VIII protein results in a blood clotting deficiency,_____.

A) a cloned mutant FVIII gene is inserted into fertilized mouse eggs, which are then transferred to a foster mother for gestation and birth
B) a cloned normal FVIII gene is inserted into fertilized mouse eggs, which are then transferred to a foster mother for gestation and birth
C) mice with similar, naturally occurring, clotting deficiencies are cloned
D) embryonic stem cells are harvested from mouse blastocysts, and grown in the lab to produce blood cells for experimental research
E) adult mice are infected with bacteria that contain a copy of a mutant human FVIII gene