At Rest,neurons Exhibit a Negative Membrane Potential

Multiple Choice

At rest,neurons exhibit a negative membrane potential.Among the factors that maintain this polarity,assess which is most DIRECTLY responsible for the difference between intracellular and extracellular ion concentrations?

A) movements of negatively charged proteins and nucleic acids across the membrane.
B) passive leakage of Na⁺ ions across the membrane.
C) passive leakage of K⁺ ions across the membrane.
D) movement of Na⁺ ions through voltage-gated Na⁺ channels.
E) movement of K⁺ ions through voltage-gated K⁺ channels.