Which of the Following Is Not a Cause of Hyporesponsiveness

Multiple Choice

Which of the following is not a cause of hyporesponsiveness?

A) Low levels of the circulating hormone
B) Abnormal receptors incapable of binding the hormone on the target tissue
C) Defects in the second messenger pathway used by a hormone and its receptor
D) Enzymes required for activation of the prohormone may be absent
E) All of the choices are causes of hyporesponsiveness