Hypercalcemia Occurs in Humoral Hypercalcemia of Malignancy (HHM)because

Multiple Choice

Hypercalcemia occurs in humoral hypercalcemia of malignancy (HHM) because:

A) tumors synthesize parathyroid hormone (PTH) ,which increases calcium levels in blood.
B) metastasizing cells synthesize calcium and release it into the circulation.
C) PTH-related protein (PTHrP) is synthesized by tumors and stimulates bone resorption.
D) osteoclasts bind tumor marker proteins and the process of bone remodeling becomes unregulated.