Which of the Following Gives Support to the Idea That

Multiple Choice

Which of the following gives support to the idea that transcription takes place in "open" regions of the chromosome?
1) The fact that 3H-uridine incorporated into newly synthesized RNA is localized around the lateral loops of the lampbrush chromosomes rather than around the condensed axes in amphibian oocytes.
2) The study of polytene chromosomes in Drosophila and other Dipteran insects
3) The study of lambrush chromosomes in human oocytes

A) 1
B) 2
C) 3
D) 1 and 2
E) All of these are correct.