Which of the Following Mutations Is/are MOST Likely to Result

Multiple Choice

Which of the following mutations is/are MOST likely to result in cell overgrowth and (eventually) may lead to cancer?

A) a gain-of-function mutation in one allele of a proto-oncogene
B) a gain-of-function mutation in one allele of a tumor suppressor gene
C) a loss-of-function mutation in one allele of a proto-oncogene
D) a loss-of-function mutation in one allele of a tumor suppressor gene
E) a null mutation in one allele of a proto-oncogene