Which of the Following Mutations in the Coding Strand of DNA

Multiple Choice

Which of the following mutations in the coding strand of DNA would be the most likely to cause a serious mutation?

A) AGA $\rarr$ CGA
B) ATA $\rarr$ TTA
C) GAA $\rarr$ AAA
D) TAA $\rarr$ TGA
E) ACT $\rarr$ AGT