Autoinhibition in the SH2 and SH3 Domains

Multiple Choice

Autoinhibition in the SH2 and SH3 domains

A) occurs when a SH2 phospho-Tyr forms a salt bridge with an Arg on SH3.
B) occurs when a SH2 phospho-Tyr binds a Pro segment on the SH3 domain,therefore blocking the active site and burying the required Tyr.
C) occurs when a salt bride forms between the active site phosphor-Tyr on SH3 and the Glu on the activation loop.
D) occurs when the salt bridge between Glu and Arg is broken.
E) None of the above is correct.